Obesity And Heart Failure: An evolving relationship…

· Heart failure may develop from obesity, according to a study published in the Journal of the American College of Cardiology March 2009.
· Investigators analyzed data from the Framingham Offspring Study and found that a certain protein released from fat cells called RESISTIN was elevated in people who went on to develop heart failure.

· Investigators state that the relationship between RESISTIN and heart failure is not completely clear.  RESISTIN appears to be a new and independent risk factor for the development of heart failure.

· RESISTIN may be part of a more complex relationship between obesity and heart function.  Obesity is associated with the development of insulin resistance, diabetes and hypertension.  Even accounting for this relationship, RESISTIN increased heart failure incidence and likely represents additional harm to heart function.

· Researches comment that it is too early to consider anti-RESISTIN medication in combating heart failure.

· Until this relationship is worked out, the best advice at this time is dieting and exercise.

Reference
Frankel DS, Vasan RS, D’Agostino RB, et al. Resistin, adiponectin, and risk of heart failure. The Framingham Offspring Study. J Am Coll Cardiol 2009; 53:754-762.

February 5, 2009

Posted on February 5, 2009

One Response to “Obesity And Heart Failure: An evolving relationship…”

  1. medicues says:
    December 12, 2009 at 11:41 pm

    Update

    Reply

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