Fatty Liver Disease

Definition
· Nonalcoholic Fatty Liver Disease is the disease of an accumulation of fat cells in the liver without alcohol use.

Overview
· Nonalcoholic Fatty Liver Disease (fatty liver) is common.
· Fatty liver disease affects up to 30% of the US population
· Fatty liver can be caused by:
obesity
Cushing syndrome
diabetes mellitus
high cholesterol / fats
high blood triglycerides
medications such amiodarone, corticosteroids, diltiazem, tamoxifen, HIV medications
polycystic ovary syndrome

Symptoms
People with Fatty Liver Disease (Nonalcoholic) do not usually have symptoms but occasionally may experience discomfort in the right upper abdominal area

Complications
· Fatty liver Disease (Nonalcoholic) usually does not lead to other illnesses but occasionally can progress to:
liver cirrhosis
liver cancer

Treatment
Fatty Liver Disease can be treated by:
dietary fat restriction
exercise
weight loss

References
Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis. Gastroenterology. 2008 Oct;135(4):1176-84.  [PMID: 18718471]
Review article: diagnosis and treatment of non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 2008 Sep 1;28(5):503-22.  [PMID: 18532991]

Posted on July 22, 2009

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